منابع مشابه
ntextual” Synthetic Lethality and/or Loss of erozygosity: Tumor Hypoxia and ification of DNA Repair
wnloade oxia exists in every solid tumor and is associated with poor prognosis because of both local and ic therapeutic resistance. Recent studies have focused on the interaction between tumor cell genetd the dynamic state of oxygenation and metabolism. Hypoxia generates aggressive tumor cell phees in part owing to ongoing genetic instability and a “mutator” phenotype. The latter may be due to ...
متن کاملYU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.
UNLABELLED Radiotherapy and DNA-damaging chemotherapy are frequently utilized in the treatment of solid tumors. Innate or acquired resistance to these therapies remains a major clinical challenge in oncology. The development of small molecules that sensitize cancers to established therapies represents an attractive approach to extending survival and quality of life in patients. Here, we demonst...
متن کاملDifferences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition.
The triple-negative breast cancer (TNBC) subtype represents a cancer that is highly aggressive with poor patient outcome. Current preclinical success has been gained through synthetic lethality, targeting genome instability with PARP inhibition in breast cancer cells that harbor silencing of the homologous recombination (HR) pathway. Histone deacetylase inhibitors (HDACi) are a class of drugs t...
متن کاملBRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability.
BRCA1 plays a critical role in the regulation of homologous recombination (HR)-mediated DNA double-strand break repair. BRCA1-deficient cancers have evolved to tolerate loss of BRCA1 function. This renders them vulnerable to agents, such as PARP inhibitors, that are conditionally 'synthetic lethal' with their underlying repair defect. Recent studies demonstrate that BRCA1-deficient cells may ac...
متن کاملSSLPred : Predicting Synthetic Sickness Lethality
Two genes in an organism have a Synthetic Sickness Lethality (SSL) interaction, if their joint deletion leads to a lower than expected fitness. Synthetic Gene Array (SGA) is a technique that helps in identifying SSL values for pairs of genes in a given set of genes. SSL interactions are useful to discover the co-expressed gene groups in the regulatory and signaling networks. Also, they are used...
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ژورنال
عنوان ژورنال: International Journal of Oral Science
سال: 2011
ISSN: 1674-2818,2049-3169
DOI: 10.4248/ijos11064